A smaller softgel than Mono Omega!

(Mono Omega has 1300 mg - Omega 650 has 650 mg)

• Positively Affects the Production of Arachidonic Acid-Derived Eicosanoids*
• Supports Cardiovascular Health*
• Supports Healthy Mental Functioning*
• Supports Healthy Glucose and Insulin Metabolism*
• By Supplying the Precursors EPA and DHA, Helps the Body Generate Specialized Proresolving Lipid Mediators, Such as Resolvins and Protectins* 

Omega 650 features natural enzymatically enhanced MaxSimil^® monoglyceride fish oil that has a three times greater EPA/DHA absorption rate than an equivalent dose of ethyl ester fish oil. This translates to less fish oil in a smaller softgel for easy swallowing. This IFOS five-star certified fish oil outperforms other fish oils through MaxSimil patented lipid absorption enhancement technology (PLATform).*

 

Supercritical Sea Buckthorn Delivers Plant-Sourced Omega Fatty Acids

• A Superfood Botanical that's a staple of traditional herbal systems
• Only Gentle Extraction Methods
• Sea Buckthorn contains Palmitoleic acid, an Omega-7 fatty acid recognized as one of Nature’s “good fats.”
• The full spectrum of beneficial compounds found in Sea Buckthorn Force is delivered using a supercritical extraction, whole-food approach to herbal supplementation.
• A superfood botanical that’s a staple of traditional herbal systems, Sea Buckthorn is also being researched for its many benefits.
• Our full-spectrum process extracts precious plant compounds to preserve Nature’s full complexity, delivering super-pure, super-potent herbal extracts.

Usage

Directions 

One softgel daily.

Ingredients

Amount per 1 Softgel		% Daily Value
Proprietary Blend	500 mg	•
Sea Buckthorn (fruit and seed) supercritical extract; Rosemary supercritical extract; Calendula supercritical extract; (Palmitoleic Acid [Omega-7 fatty acid] 100mg)		•

Other ingredients: Capsule (gelatin [Halal], vegetable glycerine, water, caramel and carob) and organic sunflower oil.

Naturally gluten free; our premium softgel capsules are BSE free.

Caution: As with any dietary or herbal supplement, you should advise your health care practitioner of the use of this product. If you are nursing, pregnant, or considering pregnancy, you should consult your health care practitioner prior to using this product.

Clinical Applications

• Supports Healthy Thiamin Status*
• Supports Vascular Health*
• Supports Nerve Health* 

Benfotiamine is a lipid-soluble derivative of thiamin that demonstrates improved absorption and duration of activity compared to water-soluble thiamin. Benfotiamine activates transketolase activity, thereby facilitating conversion of harmful glucose metabolites and positively affecting AGE formation. It supports peripheral nerve health and may support vascular health, including the microvasculature of the retina and kidney. Benfotiamine is also an excellent way to improve thiamin status.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

Does Not Contain Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.

Usage

Directions

Take two capsules in the morning and two capsules in the evening, or as directed by your healthcare practitioner. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. 

More Info

The excellent pharmacokinetic profile of lipid-soluble benfotiamine (S-benzoylthiamine O-monophosphate) is the reason why many practitioners select it in preference to other forms of supplemental thiamin, especially for protocols requiring high levels of the B vitamin. Its effectiveness, however, has been demonstrated even in low doses (i.e. 150 mg/d). As compared to thiamin hydrochloride administration, maximum plasma levels are approximately five times higher and bioavailability is, at maximum, approximately 3.6 times as high. These plasma levels are also better than lipophilic thiamin derivatives.

Pathways of Glucose-Metabolite–Induced Damage

High intracellular sugars can lead to an accumulation of intermediate metabolic products. These metabolic products activate certain pathways. These pathways are: (1) polyol pathway flux; (2) increased formation of AGEs (advanced glycation end-products); (3) increased expression of the receptor for AGEs (RAGEs) and its activating ligands; (4) activation of protein kinase C (PKC) isoforms; and (5) overactivity of the hexosamine pathway.[4] Together, these mechanisms can impact vascular tissue and target particularly susceptible capillary endothelial cells of the retina, mesangial cells in the renal glomerulus, neuronal cells, and Schwann cells.*

Benfotiamine Supports Diversion to Different Pathway

Benfotiamine has been shown to enhance the activity of transketolase, an enzyme that catalyzes the conversion of harmful glucose-intermediate metabolites in the pentose phosphate pathway. In vitro research showed treatment with benfotiamine had an impressive effect on transketolase activity (454% increase from control).[5] Researchers further indicated that increasing transketolase activity supports the diversion of intermediate metabolites away from three of the major pathways (including AGE formation) discussed above.[5] Benfotiamine was shown to have a positive influence on AGE formation and PKC activity. It is thought to prevent NF-kappaB activation in the rat retina as well as inhibit change in the number of retinal acellular capillary segments.*

This research has been supported by a human pilot study wherein subjects given benfotiamine (600 mg/d) plus alphalipoic acid (1200 mg/d) demonstrated healthy changes in AGE formation, monocyte hexosamine-modified proteins, and prostacyclin synthase activity.*

Nerve Tissue Health

Microvasculature feeding peripheral nerves can be affected by the pathways discussed herein. Furthermore, lower AGE formation is associated with healthier nerve tissue. The role of benfotiamine in diverting glucose metabolites to a less harmful metabolic pathway may well be the underlying reason it has been used successfully in Germany for over a decade to support nerve health. Results suggest that benfotiamine is most effective in large doses (320- 600 mg/d), although effectiveness is still achieved in smaller daily dosages (150 mg/d).*

750 mg - 60 tablets OR 500 mg - 120 tablets

Clinical Applications 

• Supports the Maintenance of Healthy Blood Lipids*
• Supports Normal Carotid Intima-Media Thickness (CIMT)*

Niacin is one of the most studied and documented nutrients for support of lipid levels already within the normal range, especially high-density lipoprotein cholesterol (HDL-C) levels. Sustained-release niacin, as found in Flush Free Niacin 750-Ultra Niacin, has a lesser flushing effect compared with instant-release niacin. Use of a proprietary, wax-coated technology permits release that is complete in seven to eight hours, the time that is considered ideal for a time-release form of niacin.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Ingredients

Does Not Contain

Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

 

Usage

Directions

Take one tablet one to two times daily with food, or as directed by your healthcare practitioner.

More Info

Discussion

The cardiovascular benefits of niacin (vitamin B3) were introduced in the June 1956 issue of Mayo Clinic Proceedings. More than 20 years later, the Framingham Heart Study touted the benefits of niacin on lipid metabolism. A decade later, as the study continued, researchers labeled niacin “front-line” cardiovascular support.[2] This status was further reinforced in 1988 when the National Cholesterol Education Program (NCEP) panel designated niacin a “first-line therapy” for support of specific parameters related to cardiovascular health.*

Mechanisms of Action

Several mechanisms of action have been proposed for niacin. Various experimental models suggest niacin can modulate lipoprotein biosynthesis in the liver, inhibit the release of free fatty acids from adipocytes, inhibit synthesis of apo B, induce lipoprotein lipase, and help maintain the structure and function of HDL (high-density lipoprotein) by reducing the amount of apo A-1 broken down from HDL during hepatic processing. In addition, when niacin is used with resins, it can stimulate bile flow and may therefore affect lipid biosynthesis.*

Human Trials

Since the late 1970s, studies and clinical trials, lasting from four weeks to five years with daily doses of extended-release (also known as sustained/prolonged/slow-release) niacin up to 3000 mg/day, have consistently demonstrated niacin’s efficacy and safety. In 2004, the ARBITER 6-HALTS trial clearly demonstrated that niacin offers targeted support of cardiovascular health. Final results of this trial, published in 2010, further demonstrated that niacin supports healthy carotid intima-media thickness (CIMT). While the supportive effect niacin has on blood lipids is well documented, there has been a recent focus by NCEP and other researchers on how niacin’s effect on HDL may influence cardiovascular events. More well-designed studies that address innate limitations and are carried to completion are needed.*

Why Isn’t Niacin More Widely Used?

The two common concerns are cutaneous flushing and increased liver enzymes. Cutaneous flushing is harmless, although it can be a nuisance. Flushing is most often seen with the use of immediate/ instant-release forms of niacin and can occur with doses as low as 30 mg/day, but it is more likely to occur with the much higher doses used to support healthy blood lipids. Flushing may last 10 to 15 minutes and rarely, but possibly, up to two hours. The proprietary wax-coated technology used in Flush Free Niacin 750-Ultra Niacin tablets allows a gradual, sustained release of niacin over a seven-to-eight hour period. This delivery dramatically reduces the flushing associated with immediate-release forms. Adherence to a regimen with the special wax-coated form of niacin, as found in Flush Free Niacin 750-Ultra Niacin, ranged from 88-97% in four human clinical trials. Flushing, itching, tingling, and upper gastrointestinal side effects were minimal, but did increase when dosing was increased to 2000 mg/day. It is important to note that Flush Free Niacin 750-Ultra Niacin should not be confused with “no-flush” niacin, which is inositol hexanicotinate (IHN), a supplement that does not contain any free niacin and may not be as supportive of cardiovascular health as those providing nicotinic acid.*

The second concern with regard to liver enzyme elevation was first elucidated by the results of McKenney’s study, published in 1994 in the Journal of the American Medical Association (JAMA), wherein subjects received 3000 mg/day of niacin over an extended period of time.[14] In April 2004, McKenney retracted his earlier warnings about the harmful effects of niacin and publicly supported its unique benefits. Although they generally do not enter an unhealthy range, liver enzymes may increase when initiating niacin therapy, especially in amounts greater than 1000 mg/day. Enzyme levels return to normal promptly after cessation of niacin.*

Clinical Applications 

• Supports the Natural Function of the Pineal Gland*
• Helps Support Healthy Sleep Patterns*
• May Support Antioxidant Activity and Cardiovascular Health*
• May Support Immune System Activity*

Melatonin is produced naturally in the pineal gland of the brain in response to changes in light exposure; it helps maintain healthy sleep patterns as well as antioxidant and immune activities. Melatonin can be taken as a supplement to support these functions by promoting normal levels of melatonin in the body.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

Does Not Contain 
Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives. 

Usage

Directions

Take one to two tablets 15 to 60 minutes before bedtime as directed by your healthcare practitioner. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. 

More Info

Melatonin, a naturally occurring indolamine, is produced primarily in the pineal gland but also in mammalian bone marrow, platelets, gastrointestinal tract, eyes, skin, and lymphocytes. It plays a vitally important role in regulating the body’s daily and annual biological rhythms and thus the sleep/wake cycle. Research suggests that melatonin supports antioxidant activity, cardiovascular health, and immune function as well.*

Normal melatonin secretion is suppressed by light and stimulated by periods of darkness. Nocturnal secretion of melatonin is at its highest during childhood, and then decreases with age. Studies, including meta-analyses, suggest that supplemental melatonin supports desirable sleep patterns in certain individuals, including the elderly and those who have unusual work hours, such as night shift workers or people traveling across time zones. A review of 10 trials suggests that melatonin supplementation helped support sleep patterns in individuals crossing time zones; subjects included airline passengers, airline staff, and military personnel. Daily doses between 0.5 mg to 5 mg taken at bedtime were used and found to be similarly supportive; however, the effects were greater at the higher dose. According to this review, doses higher than 5 mg do not appear to demonstrate any increased benefit.*

Human research studies suggest that melatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency (percent of time asleep to total time in bed), and awakening. In one study employing five experimental periods, melatonin appeared to positively support normal sleep initiation, maintenance, efficiency, and activity within one week of supplementation versus placebo. Another randomized, double-blind, placebo-controlled study of 33 individuals over a 16- day period suggested that the onset, quality, depth, and duration of sleep can be supported by melatonin supplementation without the occurrence of daytime drowsiness or adverse effects.*

Melatonin has been closely studied for its role in supporting antioxidant activity, especially since intracellular melatonin is concentrated in the mitochondria, a major site of oxidative metabolism. Melatonin has been found to support extracellular antioxidant activity, support glutathione production, and stimulate production of intracellular antioxidant enzymes—including superoxide dismutases and glutathione peroxidase. Research suggests that melatonin works on a number of levels. It is able to scavenge oxygen-based and nitrogen-based free radicals, and support the natural response to inflammation by promoting cytokine balance. As a lipophilic molecule, melatonin is able to permeate the lipid portion of low-density lipoprotein (LDL) and support antioxidant activity in cells. Research suggests that melatonin supports blood pressure already in the normal range and overall cardiovascular health.*

Finally, research suggests that melatonin aids immune system activity by supporting T-helper cell function, immune-specific progenitor cell production, cytokine balance, and production of mediators, such as gamma-interferon and immune-supportive interleukins.* Shop The Care Group offers melatonin in a convenient form that provides 3 mg per lozenge, sweetened with xylitol, mannitol, and natural peppermint flavor, to support healthy sleep patterns, antioxidant activity, cardiovascular health, and immune function.*

Clinical Applications

• Supports Cardiovascular and Neurological Health*
• Supports the Maintenance of Healthy Homocysteine Levels Already Within Normal Range*
• Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins* 

Ultra Methyl Folate is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range. It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic®† for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.* 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Ingredients

Does Not Contain
Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Usage

Directions

Take one to two capsules one to two times daily, or as directed by your healthcare practitioner. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

More Info

Ultra Methyl Folate provides 5-methyltetrahydrofolate (active folate), pyridoxal 5’-phosphate (active B6), methylcobalamin (active B12), riboflavin 5’-phosphate (active vitamin B2), and anhydrous betaine (trimethylglycine). These five nutrients promote the process of methylation. Methylation is the addition of a methyl group (a carbon atom with three hydrogen atoms attached) to proteins, enzymes, chemicals, DNA, or amino acids like homocysteine. It is a vital and fundamental process that takes place in many biochemical pathways involving detoxification, cardiovascular health, neurological health, eye health, muscle health, bone health, and redox balance. Effective methylation also has roles in the biosynthesis and breakdown of catecholamines, such as epinephrine. This is an important aspect of healthy adrenal functioning.*

Folic Acid (as calcium folinate and 5-methyltetrahydrofolate)

This B vitamin has important roles in detoxification, nervous system function, breast tissue health, prenatal development, and the conversion of homocysteine back to methionine. In its active form, folic acid serves as a donor of methyl groups. Providing the combination of calcium folinate and 5-methyltetrahydrofolate (5-MTHF) allows optimal utilization of folic acid by bypassing metabolic steps to bioactivity. In fact, 5-MTHF is the form into which the body must convert all other forms of folic acid before it can be used. In this formula, 5-MTHF is provided as calcium folinate and Quatrefolic®. Quatrefolic is proven to have greater stability, solubility, and bioavailability over the calcium salt forms of 5-MTHF.*

Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with large doses of folic acid can “force” its conversion to the more active form, 5-MTHF may be the preferred form to support healthy folate status. This may be especially true in those with certain variations in folate metabolism or digestion that can affect conversion of folic acid to 5-MTHF.[2-4] Folate is stored in the red blood cells, where levels have been shown to be higher after supplementation with 5-MTHF compared to folic acid and placebo. Patients given 5 mg of 5-MTHF experienced plasma levels 700% greater than patients given folic acid. In another study, authors concluded that 5-MTHF should be the primary choice of supplementation to support healthy homocysteine levels already within the normal range.*

Trimethylglycine (as anhydrous betaine)

Found in several tissues in humans, trimethylglycine acts as an alternative methyl donor in homocysteine metabolism. Trimethylglycine may also be a preventive agent against the activation of NFkappaB.*

Vitamin B12 (as methylcobalamin)

Cyanocobalamin (the form of B12 present in many supplements) has to be converted in the liver to methylcobalamin, the form provided in Ultra Methyl Folate. B12 is another methyl donor, and studies suggest that it supports healthy homocysteine levels already within the normal range on its own and in combination with folate.*

Vitamin B6 (as pyridoxal 5’-phosphate)

This coenzyme form of vitamin B6 is the primary bioactive form. It is a coenzyme in approximately 100 enzymatic reactions.[9] Data from the Framingham Study showed an inverse association between homocysteine and good B6 status (as well as B12 and folate).* Vitamin B2 (as riboflavin 5’-phosphate) As the principal coenzyme form of B2, riboflavin 5’-phosphate is used in many oxidative reactions. Folate and riboflavin interact to support healthy homocysteine levels already within the normal range, possibly by maximizing the catalytic activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). The effect may be unrelated to MTHFR genotype.*

Clinical Applications

• Supports Carbohydrate Metabolism*
• Supports Healthy Nervous System/Adrenal/Immune Function*
• Supports Cardiovascular Health*
• Supports Healthy Mental Function and Mood* 

Ultra B Complex contains the entire spectrum of B vitamins to support adrenal and neurological functions. It features activated forms of vitamins B2, B6, and B12; benfotiamine, a fat soluble, more physiologically active form of thiamine; and folate as Quatrefolic®†, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

Does Not Contain
Wheat, gluten, corn protein, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

 

Usage

Directions

Take one capsule once or twice daily, or as directed by your healthcare practitioner. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

More Info

Discussion

The water-soluble B vitamins have to be absorbed in the small intestine and then go to the liver where they are biotransformed into their active coenzyme forms. Ultra B Complex contains vitamins B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (methylcobalamin) in their physiologically-active form making them easier to absorb and “ready-for-use.” For example, in patients receiving pyridoxine HCl, only 33 percent responded with an increase in plasma pyridoxal-5’-phosphate (P5P); however, the level increased in all of the patients receiving P5P.*

Folate is provided as 5-methyltetrahydrofolate (5-MTHF), which bypasses metabolic steps to folate bioactivity. Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with large doses of folic acid can “force” its conversion to the more active form, 5-MTHF may be the preferred form to replenish folate. This may be especially applicable to those with digestive challenges or genetic variations in folate metabolism. In this formula, 5-MTHF is provided as Quatrefolic—the glucosamine salt of 5-MTHF. In vitro and in vivo studies have proven that Quatrefolic has greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF. Folate is stored in small amounts in red blood cells (RBC), and RBC folate has been shown to be higher after supplementation with 5-MTHF compared to folic acid and placebo. Likewise, patients given 5 mg of 5-MTHF experienced plasma levels of 5-MTHF 700% greater than patients given folic acid.*

Another unique ingredient in this formula is benfotiamine (S-benzoylthiamine O-monophosphate), a safe, fat-soluble analog of thiamine. One study showed that it not only raised blood and tissue levels of thiamine at least five times higher than the water-soluble salt, but it also remained bioavailable after oral administration up to 3.6 times longer than thiamine salt.  Benfotiamine is the most potent of a class of thiamine-derived compounds present in small quantities in members of the Allium genus. The superiority of its biological activity compared to thiamine rests in its structure—a thiazole ring opens to allow easy diffusion through a membrane and then closes to become structurally active.*

Benfotiamine increases transketolase activity, thereby diverting from three natural, yet destructive metabolic pathways: 1) it decreases the glucose metabolites that lead to the buildup of certain types of detrimental advanced glycation end products (AGEs); 2) it normalizes protein kinase C activity; 3) it protects the retina by preventing the activation of NF-kappaB therein. Research suggests it may also protect the kidneys and endothelial cells. Benfotiamine is useful for replenishing thiamine, this may be especially true in individuals that use the vitamin at a higher rate or in those with lifestyle habits that deplete it.*